ABSTRACT
The relationship between the severity of COVID-19, hyperinflammation, and intravascular coagulopathy is of critical importance. We report on a case of severe COVID-19 pneumonia treated with favipiravir during the earliest phase of the pandemic. The present case showed improvement in SARS-CoV-2 viral load and the presence of SARS-CoV-2 IgG with decreased radiological evidence of pulmonary infiltration. Moreover, the levels of serum IL-6 and TNF-α did not increase markedly. However, the hypoxia failed to recover, leading to the patient’s death due to possible pulmonary thrombosis, because D-dimer was markedly elevated, and an electrocardiogram showed typical changes. At present, the fact that some COVID-19 patients with mild to moderate symptoms suddenly die at home has become a major issue in Japan. These findings suggest that additional treatment with anti-coagulants should be considered in some COVID-19 patients at risk of hypercoagulation to prevent sudden death from pulmonary thrombosis.
ABSTRACT
In this paper, we estimate the effectiveness of COVID-19 contact tracing applications using agent-based simulations. We develop a simulation model and see how many infected patients can be reduced using the applications. In order to investigate the effectiveness of the applications, we enlarge the tracing area from direct contacts to indirect contacts. The results of our agent-based simulation show that detecting indirect contacts can reduce the number of infected patients. © 2021 IEEE.